Estrogen target tissues and neoplasia [proceedings] by Workshop on Estrogen Target Tissues and Neoplasia (1970 Buffalo, N.Y.)

Cover of: Estrogen target tissues and neoplasia | Workshop on Estrogen Target Tissues and Neoplasia (1970 Buffalo, N.Y.)

Published by University of Chicago Press in Chicago .

Written in English

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  • Estrogen -- Congresses,
  • Breast -- Cancer -- Endocrine aspects -- Congresses,
  • Carcinogenesis -- Congresses,
  • Target organs -- Congresses

Edition Notes

Includes bibliographical references.

Book details

StatementEdited by Thomas L. Dao.
ContributionsDao, Thomas L. 1922- ed.
LC ClassificationsQP801.E7 W67 1970
The Physical Object
Paginationxi, 369 p.
Number of Pages369
ID Numbers
Open LibraryOL4919292M
ISBN 100226136329
LC Control Number76182870

Download Estrogen target tissues and neoplasia

Workshop on Estrogen Target Tissues and Neoplasia ( Buffalo, N.Y.). Estrogen target tissues and neoplasia. Chicago, University of Chicago Press [] (OCoLC) Material Type: Conference publication: Document Type: Book: All Authors / Contributors: Thomas L Dao.

In vivo, these effects of estrogen may be direct or may be secondary to effects on estrogen-target genes within the mammary gland or target genes within peripheral tissues. A biological response to estrogenic stimulation is initiated by interaction of estrogen with cognate receptors.

Abstract. The interaction of estrogens with human target tissues has received scant attention as compared with other species. Early reports demonstrated that radioactive estradiol is concentrated by the human uterus in vivo (1), and is specifically bound in cytosol prepared from human endometrium (2,3,M.

However, a specific cytoplasmic 8S estrogen receptor similar to that found in the rat and Cited by:   Cytochrome P enzymes that metabolize estrogens are expressed in the mammary gland, uterus, brain and other target tissues for estrogen action, and this results in the formation of hydroxylated estrogens in these tissues.

Estradiol metabolites formed in target tissues at or near estrogen receptors may either be inactive or have important Cited by: The proof that hormones can influence the growth of cancer was derived from experiments by Huggins and Clark () on tumors of the prostate of the dog.

Keywords Breast Cancer Mammary Gland Advanced Breast Cancer Endometrial Carcinoma Mammary CancerAuthor: Thomas L. Dao. The estrogen level decline in menopausal status is involved in physiological alterations of different human tissues including vaginal mucosa.

In this study, we have evaluated the estrogen receptor (ER) and estrogen receptor-related receptor (ERR) expression in tissue samples of posterior vaginal wall obtained from pre- and post-menopausal women.

Types of biological samples used to measure the local estrogen levels in the breast included breast tumor tissue, normal glandular tissue distant from the tumor site, breast fat tissue and adipocytes separated from breast fat tissue, breast nipple aspirate, perfusate obtained from the breast microdialysis, benign breast lesions, and benign breast tumor.

All studies have reported some. The role of estrogen-regulated miRNA expression, the target genes of these miRNAs, and the role of miRNAs in health and disease is a “hot” area of research that will yield new insight into molecular mechanisms of estrogen action.

TARGET TISSUE: FUNCTION: Adrenocorticotropic: Pituitary gland (anterior) Adrenal cortex: Triggers secretion of hydrocortisone from the adrenal gland: Growth hormone: Pituitary gland (anterior) Throughout body: Stimulates growth and development: Follicle-stimulating hormone: Pituitary gland (anterior) Sex glands: Stimulates female egg maturation and male sperm production.

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Estrogen also has indirect positive effects on calcium metabolism and its deficiency reduces both intestinal and renal calcium absorption. In addition, estrogen is a major regulator of bone metabolism in men, and low estrogen levels are associated with increased fracture risk, even in the setting of normal testosterone levels.

The endometrial tissue is a sensitive target for steroid sex hormones and is able to modify its structural characteristics with promptness and versatility. This article discusses briefly. Bioidentical Hormones: Dr. John R. Lee's Three Rules for BHRT. Use a sprinkle of common sense and a dash of logic.

by John R. Lee, M.D. The recent Lancet publication of the Million Women Study (MWS) removes any lingering doubt that there's something wrong with conventional HRT (see Million Woman Study in the UK, Published in The Lancet, Gives New Insight into HRT and Breast Cancer for details).

Estrogens are hormones, which means that they function as signaling molecules. A signaling molecule exerts its effects by traveling through the bloodstream and interacting with cells in a variety of target tissues.

The breast and the uterus, which play central roles in sexual reproduction, are two of the main targets of estrogen. Hormones are the chemical substances which coordinate the activities of living organisms and also their growth. They are secreted by special tissues. Aromatase in mammary tissue appears to increase estrogen receptors and cause breast neoplasia, independently of ovarian estrogen (Tekmal, et al., ).

Women who have had their ovaries removed are usually told that they need to take estrogen, but animal experiments consistently show that removal of the gonads causes the tissue aromatases to increase. Estrogen, any of a group of hormones that primarily influence the female reproductive tract in its development, maturation, and function.

There are three major hormones—estradiol, estrone, and estriol—among the estrogens, and estradiol is the predominant one. Once hormones have served their function on their target organs/tissues they are destroyed. They are either destroyed by the liver or the actual tissues of the target organs.

They are then removed by the kidneys. The Pituitary Gland. This is known as the "master gland" because it exerts control over all of the other glands of the endocrine. and its regulation of gene expression in target tissues. Synthesis and Secretion of Progesterone The ovary is the major site of synthesis and secretion of estrogen and progesterone in the mammal and gives rise to cyclical fluctuations in the levels of these hormones in the circulation (reviewed in Ref.

Primary follicles play a dual. Hormones play a critical role in the regulation of physiological processes because of the target cell responses they regulate. These responses contribute to human reproduction, growth and development of body tissues, metabolism, fluid, and electrolyte balance, sleep, and many other body functions.

Estrogen causes the breast to grow by increasing breast cell numbers and their multiplication. It also stimulates the development of female sexual organs.

Estrogen decreases the function of the thyroid hormone. Estrogen increases the production of a protein called thyroid binding globulin. This protein binds the thyroid hormone making it inactive. Hormones act on nearby tissues or are carried in the bloodstream to act on specific target organs and distant tissues.

Diseases of the endocrine system can result from the oversecretion or undersecretion of hormones or from the inability of target organs or tissues to respond to hormones effectively. Estrogen receptor (ER) positive. The cells of this type of breast cancer have receptors that allow them to use the hormone estrogen to grow.

Treatment with anti-estrogen hormone (endocrine) therapy can block the growth of the cancer cells. Progesterone receptor (PR) positive. The fact that the uterus and vagina (estrogen target tissues) bound and retained [3 H]estradiol implied that a receptor molecule was necessary to initiate the cellular responses associated with estrogen used one of the early nonsteroidal antiestrogens (U,A or nafoxidine as it was later known) to demonstrate that the estrogen-binding substance in the rat uterus is a true.

Pills from Pee. The medication pictured above with the brand name Progynon was a drug used to control the effects of menopause in women. The pills first appeared in and contained the human sex hormone en secretion declines in women around the time of menopause and may cause symptoms such as mood swings and hot flashes.

A tissue becomes a target tissue when it is affected or stimulated by a specific amino acid. The target tissue has the appropriate receptors to make it susceptible to the hormone. Short-term estrogen-progestin combination therapy did not show an increase in risk. Hormone replacement therapy and estrogen-dependent cancers have been a controversial issue.

The Women's Health Initiative was a large prospective study trying to answer specific questions about hormones and their effects on the body. The results showed a 26%. Multiple endocrine neoplasia. This is a group of disorders that affect your endocrine system.

It causes tumors on at least two endocrine glands or in other organs and tissues. Antiestrogens and long-acting estrogens move estrogen receptor sites to the nucleus and maintain elevated nuclear receptor levels for a prolonged period.

The antagonistic action of antiestrogens in the uterus, however, appears to derive from their ability to effect a marked perturbation in the subcellular distribution of receptor whereby very.

Several extrahepatic target tissues or cultured cells from target tissues express estrogen-hydroxylating enzyme activities (31,47,50–82). At least nine different isoforms of cytochrome P (some are known to metabolize estradiol) have been detected in the mammary gland of the female rat (83), and several isoforms in rat and human breast are.

However, these drugs also have many estrogenic effects depending on the tissue and gene, and they are more appropriately called selective estrogen receptor modulators (SERMs).

SERMs bind ER, alter receptor conformation, and facilitate binding of coregulatory proteins that activate or repress transcriptional activation of estrogen target genes.

A class of natural or synthetic hormones that binds to a cytoplasmic receptor and initiates translocation of the hormone-receptor complex to the nucleus of target cells of tissues rich in estrogen receptors, including the endometrium, myometrium, oviduct, vagina, fallopian tube, cervix, brain, liver, placenta, ovarian cells, Leydigs cells.

Estrogen, or oestrogen, is the primary female sex is responsible for the development and regulation of the female reproductive system and secondary sex are three major endogenous estrogens in females that have estrogenic hormonal activity: estrone, estradiol, and estrane steroid estradiol is the most potent and prevalent of these.

About Neoplasia, Estrogen Dependent: Neoplasia is a medical term describing an abnormal mass of tissue (tumor) caused by an abnormal group of rapidly dividing estrogen dependant neoplasia is a type of breast tumor that is dependent on estrogen for growth.

Hormones are released into body fluids, usually blood, which carries them to their target cells where they elicit a response.

The cells that secrete hormones are often located in specific organs, called endocrine glands, and the cells, tissues, and organs that secrete hormones make up.

All major hormones circulate to virtually all tissues, but a hormone influences the activity of only those tissue cells that have receptors for it. These cells are its target cells. Hormones bring about the characteristic effects by altering target cell activity. In other words, they increase or decrease the rates of normal cellular processes.

Classification according to their tissue of origin: 1) epithelial (neoplasia of lining tissues), 2) mesenchymal (neoplasia of connective tissue derivatives), 3) germ cell (neoplasia of undifferentiated stem cells,sperm, Benign Neoplasm A neoplasm that grows without invading adjacent tissue or spreading to distant sites.

In addition to being produced by the ovaries, estrogen is also produced by the body's fat tissue. These sex hormones are involved in the growth, maintenance, and repair of reproductive tissues. The following is a list of hormones found in Homo ng is not uniform for many hormones.

For example, current North American and international usage is estrogen, gonadotropin, while British usage retains the Greek digraph in oestrogen and favors the earlier spelling gonadotrophin (from trophē 'nourishment, sustenance' rather than tropē 'turning, change').

Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone humans, ERα is encoded by the gene ESR1 (EStrogen Receptor 1).Missing: neoplasia.

The roles of hormones in selecting target cells and delivering the hormonal message. Images from Purves et al., Life: The Science of Biology, 4th Edition, by Sinauer Associates () and WH Freeman (), used with permission.

Hormones are grouped into three classes based on their structure: steroids; peptides; amines.34, articles and books. Periodicals Literature. Keyword Title Author Topic. In target tissues, estrogen acts locally either in an intracrine or paracrine way.

Production of E2 in the tissue where it regulates cellular processes is described by the term "intracrinology" [1]. intraepithelial neoplasia, and to the carcinoma. These.The endocrine glands must release the correct amount of hormones (if they release too much or too little, it is known as hormone imbalance).

Your body also needs a strong blood supply to transport the hormones throughout the body. There must be enough receptors (which are where the hormones attach and do their work) at the target tissue.

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